Decomposition Studies of Nitrosourea Derivatives of Sulfa Drugs

Author: Hung-Chen Chiang(Graduate Institute of Chemistry, National Taiwan Normal University)

Abstract：

This paper attempts to study decomposition of potential anticancer agents, N- (2-chloroethyl) -N-nitrosoureido-sulfamethoxazole (1), N- (2-chloroethyl) -N-nitrosoureido-sulfamethoxypyridazine (2), N-(2-chloroethyl) -N-nitrosoureido-sulfamethazine (3), and N- (2-chloroethyl) -N-nitrosoureido-sulfisoxazole (4) at various conditions such as solid state at room temperature and 50 °C, or in buffer solution of pH 7.4 at 37 °C. Half life time of compound (2) in pH 7.4 buffer solution shows 60 min. and this value is equal to that of anticancer drug BCNU. So compound (2) might posses an anticancer effect.

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