N─甲基─甲硫基秋水仙的葡萄糖與甘露糖衍生之合成

作者:蕭次融、廖焜熙(國立臺灣師範大學化學系)

摘要：

秋水仙素經五步驟反應合成了N-甲基-N-去乙醯-甲硫基秋水仙，為增強其水溶性，取該化合物與葡萄糖及甘露糖反應，合成了新化合物：N-甲基-N-（D-葡糖基-N-去乙醯-甲硫基秋水仙(7)及N-甲基-N-（D-甘露糖基）-N-去乙醯-甲硫基秋水仙(8)；將此兩化合物乙醯化，得到了 N-甲基-（四-氧-乙醯基-D-葡糖基）-N-去乙醯-甲硫基秋水仙(9)及N-甲基-N-（四-氧-乙醯基-D-甘露糖基）-N-去乙醯-甲硫基秋水 仙(10)，以NMR分析其結構，其生理活性尚待試驗。

《詳全文》

Synthesis of Glucosyl and Mannosyl Derivatives of N-Methylmethylthiocolchicine

Author: Khun-Shi Liao, George T. Shiau(Department of Chemistry, National Taiwan Normal University)

Abstract：

Four new glycosyl derivatives 7-10 of N-methyl-methylthiocblchicine have been prepared from colchicine through an intermediate N-methyl-N-deacetyl-methylthiocolchicine (6) and ex-amined by NMR and MS techniques. The water solubility of new compounds is increased due to the glycosyl mioety.