鍺－－四（甲基）波菲林衍生物之合成

作者:姜宏哲(國立臺灣師範大學化學研究所)

摘要：

一些波菲林、金屬波菲林及有機鍺化合物顯示抗癌作用。因此本研究合成了5種新的鍺-四（甲基）波菲林衍生物（2～6），期能在抗癌療效上有幫助。
四（甲基）波菲林（1）是由?咯和乙醛反應環成。1與四氯化鍺反應，得二氯一鍺一四（甲基）波菲林(2)。將2與礬土搖振得二羥基一鍺一四（甲基）波菲林 (3)；與溴化乙基鎂反應得二乙基一鍺一四（甲基）波菲林(4)；與溴化苯基鎂反應得到二苯基一鍺一四（甲基）波菲林(5)。由3與對一硝基酚反應得二一（對硝基酚基）者一四（甲基）波菲林(6)。

《詳全文》

Synthesis of Germanium Tetramethyl Porphyrins

Author: Hung-Cheh Chiang(Institute of Chemistry, National Taiwan Normal University)

Abstract：

Some porphyoins, metaloporphyrins and orgnogermanium compounds have antitumor ef-fects. In this study five new germanium tetramethyl porphyrins (2-6) were synthesized.
Tetramethyl porphyrin (1) is prepared from pyrrole and acetaldehyde. 1 is reacted with germanium tetrachloride give dichlorogermanium tetramethyl porphyrin (1). Hydrolysis of 2 with alumina give dihydroxy germanium tetramethyl porphrin(3). Reaction of 2 with ethylmag-nesium bromide give diethylgermanium tetramethyl prophyrin(4); reaction with phenylgerma-nium bromide give diphenylgermanium tetramethyl porphyrin(5). Treatment of 3 with 4-nitrophenol give di-(4-nitrophenoxy) germanium tetramethyl porphyrin (6).