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Synthesis of Neostigmine Methylsulfate
Author: Hung-Cheh Chiang, Tzu-Chi Kung

Abstract：

Neostigmine methlsulfate is a parasympathetic drug. After checking and improving the synthetic methods of various paper and patents, our laboratory has now found a valid and economic sythetic method, the modified Boracskii and Gellet method. The synthetic step of m-dimthylaminophenol to neostigmine in Bobranskii method is improved and the yield is increased from 51% to 92%.

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